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T37596 |
Terevalefim
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|
c-Met/HGFR
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Terevalefim (ANG-3777) is an hepatocyte growth factor (HGF) mimetic. Terevalefim selectively activates the c-Met receptor. |
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T16724 |
Razuprotafib
|
AKB-9778 |
Phosphatase
,
Others
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|
Razuprotafib (AKB-9778) is a protein tyrosine phosphatase ß (HPTPß) inhibitor (IC50: 50 nM). Razuprotafib is effective for the activation of Tie-2 and is protective against acute kidney injury. |
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T10353 |
APX-115 free base
|
Ewha-18278 free base |
NADPH-oxidase
,
NADPH
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|
APX-115 free base (Ewha-18278 free base) (Ewha-18278 free base) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kid... |
|
T1615 |
Irbesartan
|
SR-47436,BMS-186295 |
Apoptosis
,
RAAS
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|
Irbesartan (SR-47436) is an Angiotensin 2 Receptor Blocker. The mechanism of action of irbesartan is as an Angiotensin 2 Receptor Antagonist. |
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T2131 |
Articaine hydrochloride
|
Ultracaine,Articaine HCl,Hoe-045 |
Sodium Channel
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Articaine hydrochloride (Hoe-045) is a thiophene-containing local anesthetic pharmacologically similar to MEPIVACAINE. |
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T76251L |
Ac-FEID-CMK TFA
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|
Pyroptosis
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Ac-FEID-CMK TFA is a selective zebrafish GSDMEb-derived peptide inhibitor that reduces mortality and renal injury in infectious shock.Ac-FEID-CMK TFA inhibits pyroptosis in vivo, attenuates septic AKI (acute kidney injur... |
|
T10354 |
APX-115
|
Ewha-18278 |
NADPH-oxidase
|
|
APX-115 (Ewha-18278) (Ewha-18278) is a potent, orally active pan NADPH oxidase (Nox) inhibitor (Kis: 1.08 μM, 0.57 μM, and 0.63 μM for Nox1, Nox2, and Nox4). APX-115 effectively prevents kidney injury. |
|
T28222 |
5-Hydroxy-1-methylhydantoin
|
HD-003,HD003,NZ419,NZ-419,HD 003,NZ 419 |
Bradykinin Receptor
|
|
5-Hydroxy-1-methylhydantoin (HD-003) is an antioxidant potentially for the treatment of renal failure. A creatinine metabolite, 5-Hydroxy-1-methylhydantoin , a hydroxyl radical scavenger, has previously been shown to con... |
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T61262 |
ZLD2218
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|
|
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ZLD2218, a potent inhibitor of BRD4 with an IC50 value of 107 nM, has been demonstrated to mitigate kidney injury and fibrosis through extensive studies. |
|
T36509 |
U-74389G
|
U-74389G,Methylated Tirilazad |
|
|
U-74389G is an antioxidant which prevents iron-dependent lipid peroxidation. It protects against ischemia-reperfusion injury in animal heart, liver, and kidney models.[1],[2],[3],[4] |
|
T38616 |
Teprasiran
|
QPI-1002 |
|
|
Teprasiran (QPI-1002) is an RNA-based compound that transiently suppresses p53-dependent apoptosis, a process involved in the development of acute kidney injury (AKI). |
|
T68328 |
Modimelanotide
|
|
|
|
Modimelanotide is a melanocortinergic peptide drug derived from α-melanocyte-stimulating hormone (α-MSH) which was under development for the treatment of acute kidney injury. It acts as a non-selective melanocortin recep... |
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T76251 |
Ac-FEID-CMK
|
|
|
|
Ac-FEID-CMK, a potent peptide inhibitor derived from zebrafish-specific GSDMEb, effectively reduces mortality and kidney injury during septic shock by inhibiting pyroptosis and mitigating acute kidney injury (AKI) in viv... |
|
T79790 |
ALPK1-IN-3
|
|
NF-κB
|
|
ALPK1-IN-3,serves as an ALPK1 inhibitor that dampens proinflammatory gene expression in the kidney and enhances survival in animal models of sepsis-induced acute kidney injury [1]. |
|
T81267 |
RIPK3-IN-4
|
|
RIP kinase
|
|
RIPK3-IN-4 (Compound 42) is a RIPK3 inhibitor that mitigates necroptosis, inflammatory responses, and HK-2 cell damage. It alleviates acute kidney injury by attenuating Cisplatin- and I/R-induced kidney damage, along wit... |
|
T78802 |
SIRT5 inhibitor 6
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|
Sirtuin
|
|
SIRT5 Inhibitor 6 is a potent, selective, and substrate-competitive inhibitor of SIRT5, exhibiting an IC50 of 3.0 μM, and demonstrates therapeutic potential for treating septic acute kidney injury (AKI) in vivo [1]. |
|
T73404 |
Dalargin
|
|
|
|
Dalargin, a potent δ-opioid receptor agonist, demonstrates efficacy in mitigating cell death induced by Gentamicin and exhibits nephroprotective effects against Gentamicin-induced kidney injury. Additionally, Dalargin po... |
|
T75268 |
84-B10
|
|
|
|
84-B10, a derivative of 3-phenylglutaric acid, inhibits cisplatin-induced tubular ferroptosis, attenuates mitochondrial damage and oxidative stress, and ameliorates acute kidney injury (AKI) resulting from cisplatin admi... |
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T81177 |
Ser@TPP@CUR
|
|
|
|
Ser nM TPP nM CUR, a derivative of Curcumin, notably mitigates damage in renal tubular epithelial cells and enhances renal function in mice with acute kidney injury (AKI). This compound holds potential for AKI research a... |
|
T82189 |
HMGB1-IN-2
|
|
|
|
HMGB1-IN-2 (compound 15) is a selective inhibitor of the highly conserved nuclear protein HMGB1, demonstrating no inhibitory effect at an IC50 of 20.2 μM in RAW264.7 cells. At a concentration of 30 μM, HMGB1-IN-2 reduces... |
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T62298 |
PHD2/HDACs-IN-1
|
|
|
|
PHD2/HDACs-IN-1 is a potent mixed inhibitor of PHD2/HDACs, acting on PHD2 (IC50: 1.15 μM), HDAC1 (IC50: 19.75 μM), HDAC2 (IC50: 26.60 μM), HDAC16 (IC50: 15.98 μM). HDACs-IN-1 is a low toxicity nephroprotective agent that... |
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T78803 |
SIRT5 inhibitor 7
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|
Sirtuin
|
|
SIRT5 inhibitor 7 (compound 58), a selective and substrate-competitive SIRT5 inhibitor, exhibits anti-inflammatory properties by modulating protein succinylation and attenuating pro-inflammatory cytokine release. It demo... |
|
T73337 |
Articaine
|
Hoe-045 free base |
|
|
Articaine (Hoe-045 free base), an amide anesthetic featuring an ester group, effectively relieves pain by reversibly binding to the α-subunit of the voltage-gated sodium channels located in the nerve's inner cavity. Furt... |
|
T60316 |
AV123
|
|
|
|
AV123 (compound 12) is a non-cytotoxic RIPK1 inhibitor with IC 50 of 12.12 μM. AV123 blocks the TNF-α-induced necroptotic with EC 50 of 1.7 μM, but not the apoptotic cell death. AV123 can be used in the study of necrotic... |
|
T83770 |
Klotho-derived Peptide 1 (56-87) (human) TFA
|
KP1 (56-87) |
|
|
Klotho-derived peptide 1 (KP1) (56-87), a peptide originating from the human Klotho protein, disrupts TGF-β signaling by binding to TGF-β receptor types 1 and 2 (TGFBR1 and TGFBR2; Kds = 1.41 and 14.6 µM, respectively). ... |
